Fibronectin - Wikipedia
WEBFibronectin is a high-molecular weight (~500-~600 kDa) glycoprotein of the extracellular matrix that binds to membrane-spanning receptor proteins called integrins. Fibronectin also binds to other extracellular matrix proteins such as collagen, fibrin, and heparan sulfate proteoglycans (e.g. syndecans).
Fibronectin - an overview | ScienceDirect Topics
WEBFibronectin is a critically important ECM protein that mediates cell:ECM interaction during fundamental events such as development, wound healing, fibrosis, and tumor progression (Schwarzbauer and DeSimone, 2011). Fibronectin is secreted as a soluble, covalently bound dimer of ~440 kD molecular weight. Fibronectin is encoded by a single gene ...
Fibronectin: Molecular Structure, Fibrillar Structure and ...
WEBSep 16, 2021 · The extracellular matrix (ECM) plays a key role as both structural scaffold and regulator of cell signal transduction in tissues. In times of ECM assembly and turnover, cells upregulate assembly of the ECM protein, fibronectin (FN). FN is assembled by cells into viscoelastic fibrils that can bind upward of 40 distinct growth factors and cytokines.
Fibronectin: Molecular Structure, Fibrillar Structure and ... - PubMed
WEBSep 16, 2021 · In this review, we will discuss the assembly of FN fibrils from individual FN molecules; the composition, structure, and mechanics of FN fibrils; the interaction of FN fibrils with other ECM proteins and growth factors; the role of FN in transmitting mechanobiology signaling events; and approaches for studying the mechanics of FN fibrils.
Fibronectin - an overview | ScienceDirect Topics
WEBFibronectin. Fibronectin (FN) is an abundant and developmentally necessary protein of the extracellular matrix (ECM) that is ubiquitously distributed in tissue and present in circulation. From: Biochemistry of Collagens, Laminins and Elastin (Third Edition), 2024
Fibronectin in Fracture Healing: Biological Mechanisms and …
WEBApr 16, 2021 · Abstract. The importance of extracellular matrix (ECM) proteins in mediating bone fracture repair is evident, and fibronectin (FN) has emerged as a pivotal regulator of this process. FN is an evolutionarily conserved glycoprotein found in all tissues of the body, and functions in several stages of fracture healing.
Fibronectin - an overview | ScienceDirect Topics
WEBDefinition. Fibronectin, an abundant and ubiquitous protein of the extracellular matrix, forms a fibrillar network by interacting directly with cell surface receptors [2 ]. It is synthesized by a variety of different cells and is secreted as a disulfide-bonded dimer with 230–270 kDa subunits ( Figure 43.1 ).
Plasma and cellular fibronectin: distinct and independent …
WEBSep 16, 2011 · Fibronectin (FN) is a ubiquitous extracellular matrix (ECM) glycoprotein that plays vital roles during tissue repair. The plasma form of FN circulates in the blood, and upon tissue injury, is incorporated into fibrin clots to exert effects on platelet function and to mediate hemostasis.
13.4: Fibronectins - Biology LibreTexts
WEBFibronectin expression along very specific pathways are crucial for the migration of neural crest and other cell types in development. In vitro experiments with fibroblasts and other cell types show a marked preference for areas coated with …
Fibronectin: a brief overview of its structure, function, and ...
WEBSpecific domains allow fibronectin to promote cell-to-cell adhesion, cell-to-basement-membrane attachment, clot stabilization, embryogenesis, nerve regeneration, fibroblast migration, macrophage function, and pathogen (virus, fungus, bacteria, and protozoa) binding to mammalian cells and extracellular matrix.
- Some results have been removed
Skip to content